Pilot Studies of Estrogen-Related Physical Findings in Infants
Judy C. Bernbaum,1 David M. Umbach,2 N. Beth Ragan,3 Jeanne L. Ballard,4 Janet I. Archer,5 Holly Schmidt-Davis,6 and Walter J. Rogan3
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18335112
Our study, although small and primarily cross sectional, suggests choices among responses for further studies. For example, our data suggest that genitalia do not vary much by age and thus will not respond to exogenous estrogen with delayed regression. Breast tissue did appear responsive, as did vaginal wall cells. Withdrawal vaginal bleeding and breast milk are worth noting but are infrequent. This study was a pilot and too small for reliable inference about feeding regimens. Our results indicate that these methods can be used validly and repeatably in infants; they may allow more direct, interpretable investigations of the infant’s response to estrogen-like compounds.
Judy C. Bernbaum,1 David M. Umbach,2 N. Beth Ragan,3 Jeanne L. Ballard,4 Janet I. Archer,5 Holly Schmidt-Davis,6 and Walter J. Rogan3
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18335112
Our study, although small and primarily cross sectional, suggests choices among responses for further studies. For example, our data suggest that genitalia do not vary much by age and thus will not respond to exogenous estrogen with delayed regression. Breast tissue did appear responsive, as did vaginal wall cells. Withdrawal vaginal bleeding and breast milk are worth noting but are infrequent. This study was a pilot and too small for reliable inference about feeding regimens. Our results indicate that these methods can be used validly and repeatably in infants; they may allow more direct, interpretable investigations of the infant’s response to estrogen-like compounds.
Glg, Gerhild
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Mag. man eben.
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Mag. man eben.